Van de Ven Brace Halts The Toffees' Unbeaten Streak at Brand New Stadium
The Dutch defender emerged as the initial backline player to score twice in a Premier League game for Spurs since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender nods home two times in opening period
Everton's defender has goal ruled after VAR review
Pape Matar Sarr scores final goal in dying moments
The defeat is the Merseyside club's first at their new ground
Micky van de Ven found the net on two occasions as Tottenham prolonged their winning streak in away games in the Premier League and handed Everton their initial loss at Hill Dickinson Stadium.
Everton were undefeated in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after more than a century at the end of the previous campaign.
But Spurs captain the Dutchman struck twice from set-pieces in the first half to put their impressive record at risk, and they were unable to mount a comeback before the midfielder - set up by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
The Everton defender thought he had levelled the scores a short while after the defender's opener, glancing a powerful header past the Spurs keeper from an Everton corner.
Beto, in the meantime, missed a handful of chances, while Vicario made a succession of fine saves to guarantee the London club went five away games unbeaten in the Premier League.
But the video assistant referee intervened, instructing the match official to check the score on the pitchside monitor and the official decided that Jack Grealish and the attacker were in offside positions and had impeded with the Spurs keeper.
This victory moves the manager's side up to third in the Premier League, five points off north London rivals and table-toppers the Gunners.
Everton stay in 14th position and are half a dozen points ahead of the drop zone.
Spurs breakdown: The defender fulfils role at each end of pitch
After a drab midweek performance in the Champions League against Monaco, where they mustered a mere two shots on goal, the manager opted for the French striker up front instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the end.
Centre-back the Dutchman transformed into an offensive threat to be reckoned with.
Spurs' opening strike came from a well-worked set-piece play, with the midfielder directing the ball back across the face of goal for an unmarked Van de Ven to score.
And Ven de Ven - filling in as captain in the Argentine's absence - notched his next goal in added time as he rose above the England keeper to nod in.
The Dutchman was just as impressive in defensive duties, partnering well with Kevin Danso as the pair dealt superbly with the 34 crosses sent their way by Everton.
Toffees breakdown: Toffees missing finishing touch
Everton's recent stadium had been a fortress, but it seems the novelty may have worn off slightly and fans headed to the exits after the midfielder's third for Tottenham.
The break in Everton's unbeaten home run won't be a major concern for the manager, but their striker situation will be.
Beto and Thierno Barry - the Everton's two established strikers - had netted just one league goal between them before the weekend's match.
And they were unable to add to that poor tally on a wet and gloomy evening on Merseyside.
The striker's performance was epitomized when he chose to bicycle-kick a clear chance from close range, despite having room and time to readjust for a simpler attempt that would have tested Vicario.
Barry, as well, was unable to make an impact after replacing Beto in the 65th minute.
It wasn't for a shortage of opportunity. The majority of Everton's attacks came through the winger and Ndiaye, who tirelessly whipped threatening balls into the Tottenham penalty area.
Upcoming fixtures for both teams?
Everton: Moyes' men travel to the Stadium of Light in the top flight on Monday, 3 November at 8 PM.
Tottenham: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup match against Newcastle.